Vincristine sulfate
Marqibo, Oncovin, Vincasar, Vincrex (vincristine sulfate) is a small molecule pharmaceutical. Vincristine sulfate was first approved as Oncovin on 1982-01-01. It is used to treat hodgkin disease, leukemia, neuroblastoma, non-hodgkin lymphoma, and rhabdomyosarcoma amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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Vincristine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MARQIBO KIT | Acrotech Biopharma | N-202497 DISCN | 2012-08-09 | 1 products, RLD |
| ONCOVIN | Eli Lilly | N-014103 DISCN | 1982-01-01 | 3 products, RLD |
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1275 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 52 | 88 | 41 | 22 | 14 | 193 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 37 | 89 | 38 | 5 | 3 | 149 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 25 | 38 | 15 | 4 | 6 | 79 |
| Follicular lymphoma | D008224 | — | C82 | 16 | 19 | 16 | 2 | 1 | 45 |
| T-cell lymphoma peripheral | D016411 | — | — | 12 | 20 | 7 | 2 | 1 | 37 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 10 | 23 | 8 | 1 | — | 35 |
| Burkitt lymphoma | D002051 | — | C83.7 | 12 | 14 | — | 2 | — | 25 |
| B-cell lymphoma | D016393 | — | — | 11 | 10 | 4 | 1 | — | 22 |
| Retinoblastoma | D012175 | — | — | 3 | 10 | 6 | 1 | 2 | 21 |
| Neoplasms | D009369 | — | C80 | 11 | 5 | 2 | 1 | 2 | 20 |
Show 11 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 24 | 108 | 55 | — | 15 | 191 |
| Leukemia | D007938 | — | C95 | 10 | 43 | 32 | — | 8 | 86 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 15 | 20 | 16 | — | 4 | 55 |
| Central nervous system neoplasms | D016543 | — | — | 7 | 20 | 13 | — | 5 | 43 |
| Hodgkin disease | D006689 | — | C81 | 6 | 22 | 15 | — | 2 | 41 |
| Sarcoma | D012509 | — | — | 5 | 19 | 11 | — | 3 | 38 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 4 | 15 | 2 | — | 3 | 22 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 10 | 7 | — | 1 | 20 |
| Rhabdomyosarcoma | D012208 | — | — | 5 | 11 | 6 | — | 1 | 19 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 5 | 8 | 4 | — | 2 | 18 |
Show 43 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 6 | 4 | — | — | — | 7 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 4 | 5 | — | — | — | 7 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 3 | 5 | — | — | — | 7 |
| Aids-related lymphoma | D016483 | EFO_1001365 | — | 1 | 5 | — | — | — | 6 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | 1 | 5 | — | — | — | 5 |
| Plasmablastic lymphoma | D000069293 | — | C83.3 | 4 | 3 | — | — | — | 5 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | 3 | — | — | — | 5 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | 2 | — | — | — | 4 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 2 | 3 | — | — | — | 4 |
| Lymphoid leukemia | D007945 | — | C91 | 2 | 1 | — | — | — | 3 |
Show 48 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 2 | — | — | — | — | 2 |
| Pinealoma | D010871 | — | — | 1 | — | — | — | 1 | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Deltaretrovirus infections | D006800 | EFO_1001303 | — | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
| Composite lymphoma | D058617 | — | — | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 2 | 2 |
| Constipation | D003248 | HP_0002019 | K59.0 | — | — | — | — | 2 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Ataxia telangiectasia | D001260 | Orphanet_100 | G11.3 | — | — | — | — | 1 | 1 |
| Ototoxicity | D000081015 | — | — | — | — | — | — | 1 | 1 |
| Nerve degeneration | D009410 | HP_0002180 | — | — | — | — | — | 1 | 1 |
| Neural conduction | D009431 | — | — | — | — | — | — | 1 | 1 |
| Pituitary neoplasms | D010911 | — | — | — | — | — | — | 1 | 1 |
| Sertoli-leydig cell tumor | D018310 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vincristine sulfate |
| INN | vincristine |
| Description | Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 2068-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL501867 |
| ChEBI ID | 79401 |
| PubChem CID | 5978 |
| DrugBank | DBSALT000314 |
| UNII ID | 5J49Q6B70F (ChemIDplus, GSRS) |
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
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Marqibo – Spectrum Pharmaceuticals
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64,091 adverse events reported
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