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AboutPricing
Drug ReportsVincristine sulfate
Vincristine sulfate
Vincristine (vincristine sulfate) is a small molecule pharmaceutical. Vincristine sulfate was first approved as Oncovin on 1982-01-01. It is used to treat hodgkin disease, leukemia, neuroblastoma, non-hodgkin lymphoma, and rhabdomyosarcoma amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
immune system diseasesD007154
Trade Name
FDA
EMA
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Status
Last Update
vincristine sulfateANDA2026-02-17
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CA: Vinca alkaloids and analogues, antineoplastic
— L01CA02: Vincristine
HCPCS
Code
Description
J9370
Vincristine sulfate, 1 mg
J9371
Injection, vincristine sulfate liposome, 1 mg
Clinical
Clinical Trials
1386 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223—C85.9—1———1
B-cell chronic lymphocytic leukemiaD015451—C91.111———1
Reactive arthritisD016918EFO_0007460M02.311———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
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Ph 4
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Total
Neoplasm metastasisD009362EFO_0009708—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral nervous system diseasesD010523—G64————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVincristine sulfate
INNvincristine
Description
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Classification
Small molecule
Drug classvinca alkaloids
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Structure (InChI/SMILES or Protein Sequence)
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O
Identifiers
PDB—
CAS-ID2068-78-2
RxCUI—
ChEMBL IDCHEMBL501867
ChEBI ID79401
PubChem CID5978
DrugBankDBSALT000314
UNII ID5J49Q6B70F (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Q9CY33
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
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Variants
No data
Financial
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$
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Marqibo – Spectrum Pharmaceuticals
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Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,878 documents
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Safety
Black-box Warning
Black-box warning for: Vincristine sulfate
Adverse Events
Top Adverse Reactions
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30,931 adverse events reported
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