Vincristine sulfate
Vincristine (vincristine sulfate) is a small molecule pharmaceutical. Vincristine sulfate was first approved as Oncovin on 1982-01-01. It is used to treat hodgkin disease, leukemia, neuroblastoma, non-hodgkin lymphoma, and rhabdomyosarcoma amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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Abbreviated New Drug Application (ANDA)
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| vincristine sulfate | ANDA | 2024-04-24 |
Indications
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Clinical
Clinical Trials
1345 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | — | 1 | 1 | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | 1 | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasmablastic lymphoma | D000069293 | — | C83.3 | 8 | 7 | — | — | — | 12 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | 8 | 7 | — | — | — | 12 |
| Aids-related lymphoma | D016483 | EFO_1001365 | — | 4 | 8 | — | — | — | 12 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 7 | — | — | — | 9 |
| Hematologic neoplasms | D019337 | — | — | 5 | 2 | — | — | 2 | 8 |
| Blast crisis | D001752 | — | — | 1 | 6 | — | — | — | 7 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | 6 | — | — | — | 7 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | — | 6 | — | — | — | 6 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | 3 | — | — | — | 5 |
| Vomiting | D014839 | — | R11.1 | — | 1 | — | — | 3 | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pinealoma | D010871 | — | — | 2 | — | — | — | 1 | 3 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Deltaretrovirus infections | D006800 | EFO_1001303 | — | 1 | — | — | — | — | 1 |
| Htlv-i infections | D015490 | EFO_0007316 | — | 1 | — | — | — | — | 1 |
| Composite lymphoma | D058617 | — | — | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | — | — | — | 1 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nausea | D009325 | — | R11.0 | — | — | — | — | 3 | 3 |
| Constipation | D003248 | — | K59.0 | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 1 | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Ataxia | D001259 | — | R27.0 | — | — | — | — | 1 | 1 |
| Ataxia telangiectasia | D001260 | Orphanet_100 | G11.3 | — | — | — | — | 1 | 1 |
| Telangiectasis | D013684 | — | — | — | — | — | — | 1 | 1 |
| Cerebellar ataxia | D002524 | — | — | — | — | — | — | 1 | 1 |
| Ototoxicity | D000081015 | — | — | — | — | — | — | 1 | 1 |
| Nerve degeneration | D009410 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vincristine sulfate |
| INN | vincristine |
| Description | Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 2068-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL501867 |
| ChEBI ID | 79401 |
| PubChem CID | 5978 |
| DrugBank | DBSALT000314 |
| UNII ID | 5J49Q6B70F (ChemIDplus, GSRS) |
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
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Marqibo – Spectrum Pharmaceuticals
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Safety
Black-box Warning
Black-box warning for: Vincristine sulfate
Adverse Events
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91,418 adverse events reported
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